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Dr. Kevin Lam





E-Mail:kevin.lam 'at' nu.edu.kz
Office:7.112
Phone:+7 (7172) 70 91 10







Dr. Kevin Lam received his Ph.D. in Medicinal and Synthetic Organic Chemistry from the Catholic University of Louvain in Belgium. His doctoral work explored the use of electrochemistry and photochemistry as green alternatives to activate organic molecules.This work resulted in the development of a new radical-based deoxygenation reaction (the Lam-Marko reaction).

After his Ph.D., he moved to the University of Vermont (UVM). His research focused on applying analytical/physical electrochemistry alongside spectroscopy to study the complex redox behaviour of organometallic compounds.

This work bolstered the use of weakly coordinating electrolytes/solvents as an electrochemical medium to allow for the generation and characterisation of highly reactive and unstable 17e- organometallic radical-cations. Additional work at UVM led to the pioneering of a new method to modify electrode surfaces through an ethynyl linkage. The covalent attachment of molecules to an electrode surface is fundamental to the field of molecular electronics and numerous material applications.

Grants

2015

Ministry of Education and Science - In collaboration with Sandia National Lab and University of New Mexico . 
"Study and Preparation of New CO2 reduction electrocatalysts"

University of Vermont Cancer Center Research Grant - In collaboration with the University of Vermont Cancer Center and Fletcher Allen Hospital. 
"Pre-clinical Anti-cancer Studies of Novel Organometallic Derivates"

2014

Oak Ridge Associated Universities / Nazarbayev University Grant - In collaboration with the University of Vermont Cancer Center and Fletcher Allen Hospital. 
"Medicinal Electrochemistry - Preparation of New Organometallic Tyrosine Kinases"

Nazarbayev University SEED Grant
"Electrochemical Activation of Benzoic Acids: A New Way of Access to Benzoyl Oxy Radicals"

Patents

2016    WO PCT/US16/12050 “New Compounds and uses thereof for inhibition of cell growth”. Inventors: Kevin Lam, William E. Geiger and Claire Verschraegen. 

2015     Provisional “Use of Cymanquine Compounds as Antimalarial Agents”. Inventors: Kevin Lam, William E. Geiger and Lawrence Bergman. 

2015    US 62/099,335 “New Compounds and uses thereof for inhibition of cell growth”. Inventors: Kevin Lam, William E. Geiger and Claire Verschraegen.5

Representative Publications

Peer Reviewed Articles

“Nickel(II) and Nickel(0) complexes of bis(diisopropylphosphino)amine:  Synthesis, Structure and Electrochemical Activity” Dickie D. A., Chacon B. E., Issabekov A., Lam K., Kemp R. A., 2016, Inorg. Chim. Acta, 2016, 453, 42

“Synthesis and Anodic Electrochemistry of Cymanquine and Related Complexes” Lam K., Geiger W. E., J. Organomet. Chem., 2016, 817, 15.

“Anodic Methods for Covalent Attachment of Ethynylferrocenes to Electrode Surfaces: Comparison of Ethynyl Activation Processes” Sheridan M. V.,  Lam K., Sharafi M., Schneebeli S. T., Geiger W. E., Langmuir, 2016, 10.1021/acs.langmuir.6b00012

“Electron-transfer catalyzed cycloaddition reactions of unactivated cyclic olefins in weakly coordinating anion electrolyte”, Stewart P. M., Lam K., Chong D., Geiger W. E., J. Electroanal. Chem., 2015, 743, 68.

“Spontaneous Attachement of Lithium-Activated FerrocenylAlkynes to Carbon and Gold”, Sheridan M. V., Lam K., Geiger W. E., Electrochem. Commun., 2015, 52, 63.

“Influence of Cyclopentadienyl Ring-Tilt on Electron-Transfer Reactions: Redox-Induced Reactivity of Strained [2] and [3]Ruthenocenophanes”, Russell A. D., Gilroy J. B., Lam K., Haddow M. F., Harvey J. N., Geiger W. E., Manners I., Chem. Eur. J., 2014, early view - DOI: 10.1002/chem.201403512.

“Polyferrocenylsilane Homopolymers and Diblock Copolymers with Pendant Ruthenocenyl Groups by Photocontrolled Ring-Opening Polymerisation”, Erhard M., Lam K., Haddow M., Whittell G. R., Geiger W. E., Manners I., Polym. Chem., 2014, 5, 1264.

“Covalent attachment of porphyrins and ferrocenes to electrode surfaces through direct anodic oxidation of terminal ethynyl groups” Sheridan M. V., Lam K., Geiger W. E., Angew. Chem. Int. Ed., 2013, 49, 12897 VIP Article

“Anodic Oxidation of Disulfides: Detection and Reactions of Disulfide Radical Cations” Lam K., Geiger W. E., J. Org. Chem., 2013, 78, 8020

“An Anodic Method for Covalent Attachment of Molecules to Electrodes Through an Ethynyl Linkage” Sheridan M.V., Lam K., Geiger W.E., J. Am. Chem. Soc., 2013, 135, 2939

“Metal-Metal Bond Formation Between [n]Metallocenophanes: Synthesis and Characterization of a Dicarba[2]Ruthenocenophanium Dimer”, Russell A. D., Gilroy J. B., Lam K., Haddow M. F., Harvey J. N., Geiger W. E., Manners I. Chem. Eur. J., 2012, 18, 8000

“One pot electrochemical deoxygenation of primary alcohols”, Lam K., Markó I. E.  Synlett, 2012, 23, 1235

“Novel Electrochemical Deoxygenation Reaction Using Diphenylphosphinates”, Lam K., Markó I. E. Org. Lett., 2011, 13, 406.

"Toluates: Unexpectedly Versatile Reagents", Lam K., Markó I. E. Tetrahedron Symposium-in-Print : Electron-transfer reagents in organic synthesis, 2009, 65, 10930.

"Chemoselective chemical and electrochemical deprotection of Toluates", Lam K., Markó I. E. Synfact, 2009, 9, 1023.

"Chemoselective chemical and electrochemical deprotection of aromatic esters", Lam K., Markó I. E. Org. Lett., 2009, 11, 2752.

"Organic electrosynthesis using toluates as simple and versatile radical precursors", Lam K., Markó I. E. Chem. Comm., 2009, 95.

"Using toluates as simple and versatile radical precursors", Lam K., Markó I. E.
Org. Lett., 2008, 10, 2773.

Book

Lam K., W. E. Geiger., “One- and Two-Electron Transfer Reactions” in Organic Electrochemistry 5th edition, H. Lund and B. Speiser, Taylor & Francis, Under publication.