Assel received her master in Science in Drug Chemistry from Newcastle University, UK on the following topic: "Discovery of Antibiotics from Novel Actinomycetes" under the supervision of Dr. Nicholas Allenby (Demuris Ltd., UK) and Dr. Michael John Hall.
The main aim of her project was the identification and isolation of natural compounds exhibiting antibacterial activity from actinomycetes. Fermentation of the microorganisms was performed followed by isolation and purification of compounds with antibacterial activity employing a variety of techniques, including extraction using adsorption resin, liquid-liquid phase extraction, HPLC (High Performance Liquid Chromatography) and size exclusion chromatography. The novelty of the purified bioactive compounds was determined by comparison of the accurate mass obtained through MS (Mass Spectrometry) analysis with the Dictionary of Natural Products. Two different strains were investigated, where one of them produces a novel wide-spectrum antibiotic compound as it exerts antibacterial activity against both Gram-positive and Gram-negative bacteria.
Distribution of Antibiotics from microbial natural products
Assel is now working on the electrochemical activation of benzoic acid derivatives within the Lam group.
Representative Publication and Conferences
Assel Baibek, Aliya S. Mussabekova, Talgat S. Seitembetov, Study of antioxidant activity of some plant extracts. Materials of II International conference on natural products: technology and medical perspectives, Almaty, 2007, P.156.[Eng]
E.M. Suleimenov, A.Baibek, A.Mussabekova, Zh.K.Mussalimov, T.S. Sitembetov, S.B. Rakhmadieva, Study of antioxidant activity extracts of HALOXYLON APHYLLUM (MINKW). Materials of II International scientific-practice conference “ Essential problems of ecology and nature management in Kazakhstan and adjoining areas”, Pavlodar, 2007, 240-241.[Rus]
A. Baibek, B.I. Tuleuov, T.S. Seitembetov, Quercetin and its derivatives’ chemical modification and study of their “structure-activity” interconnection. Materials of republican scientific-theoretic conferece named «Readings from Saken-5», Astana, 2009, part II, P.276.[Eng]
A. Baibek, B.I. Tuleuov, A.Zh. Nazarova, etc., New derivative of quercetin and studies of its antioxidant activity, 8th International Symposium on the Chemistry of Natural Compounds, Eskesehir, Turkey, 2009, P.126 [Eng].
A.S. Mussabekova, A. Baibek, T.S. Seitembetov, Making an evaluation for antioxidant activity determining examination, Karaganda University Reporter, Chemistry Issue 2 (58), 2010, P.101-105 [Kaz].
2012 International Conference on Environment, Chemistry and Biology (ICECB 2012), December 29-30 2012, Hong Kong